AOD9604
AOD-9604 is a synthetic peptide derived from a small segment of human growth hormone. It corresponds to amino acids 176–191 from the C-terminal region of the growth hormone molecule, a portion associated with the regulation of fat metabolism. The concept behind its design is to isolate the lipolytic (fat-metabolizing) activity of growth hormone while avoiding the broader systemic effects linked to the full-length hormone, such as insulin resistance and unwanted tissue growth.
AOD9604
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AOD-9604 is a synthetic peptide derived from a small segment of human growth hormone. It corresponds to amino acids 176–191 from the C-terminal region of the growth hormone molecule, a portion associated with the regulation of fat metabolism. The concept behind its design is to isolate the lipolytic (fat-metabolizing) activity of growth hormone while avoiding the broader systemic effects linked to the full-length hormone, such as insulin resistance and unwanted tissue growth.
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AOD-9604 selectively targets the region associated with fat metabolism while leaving IGF-1 and insulin signalling pathways unaffected. This selectivity makes it useful in research settings where the goal is to examine lipolysis without the confounding influences of growth promotion, glucose regulation changes, or broader anabolic effects.
Studies suggest AOD-9604 may act through several pathways:
- Interacts with receptors on white adipose tissue
- Supports the release of stored triglycerides into free fatty acids and glycerol for energy utilization.
- May reduce the formation of new fat from excess carbohydrates.
- Support for cartilage matrix maintenance and repair, potentially via growth factor pathways independent of fat metabolism.
Common research areas:
- Obesity and metabolic regulation studies
- Fat oxidation and adrenergic signalling pathways
- Cartilage repair and osteoarthritis models
- Metabolic syndrome and lipid profile research
- Comparative studies of growth hormone fragments and IGF-1–independent mechanisms
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