XT100
XT100, also known as T100-Mut, is a synthetic cell-permeable peptide derived from the C-terminal region of the mutant transmembrane protein TMEM100 (Tmem100-3Q). The peptide is modified with an N-terminal myristoyl group to facilitate cellular uptake and is widely used as a research tool for investigating transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) signalling.
XT100
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XT100, also known as T100-Mut, is a synthetic cell-permeable peptide derived from the C-terminal region of the mutant transmembrane protein TMEM100 (Tmem100-3Q). The peptide is modified with an N-terminal myristoyl group to facilitate cellular uptake and is widely used as a research tool for investigating transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) signalling.
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Experimental investigations have demonstrated that the peptide enhances the association between these two ion channels, thereby inhibiting TRPA1-mediated signalling through a TRPV1-dependent mechanism. This unique mode of action has made T100-Mut a valuable experimental probe for studying receptor complex formation, ion channel modulation, and pain signalling pathways in laboratory models. Research has shown that the peptide reduces TRPA1-mediated calcium influx and attenuates pain-related behaviours in experimental models, supporting its utility as a mechanistic research tool for ion channel biology and sensory neuroscience.
Ongoing studies seek to better understand how modulating ion channel complexes influences nociceptive signalling, neurogenic inflammation, and sensory physiology, while exploring their broader applications in pain research and ion channel biology.
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