ACE-031
ACE-031 is a soluble form of the activin receptor type IIB (ActRIIB) linked to an IgG1-Fc fragment. It acts as a ligand trap by binding and blocking myostatin, activin, GDF-11, and other TGF-β family proteins that typically limit muscle growth. This allows researchers to study how myostatin signalling affects muscle development and hypertrophy.
ACE-031
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ACE-031 is a soluble form of the activin receptor type IIB (ActRIIB) linked to an IgG1-Fc fragment. It acts as a ligand trap by binding and blocking myostatin, activin, GDF-11, and other TGF-β family proteins that typically limit muscle growth. This allows researchers to study how myostatin signalling affects muscle development and hypertrophy.
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ACE-031 is a fusion protein made by combining the extracellular ligand-binding part of the ActRIIB receptor with a human IgG1 Fc region. Under normal conditions, these growth factors attach to ActRIIB and activate signals that inhibit muscle protein synthesis and limit growth. ACE-031 circulates in the bloodstream and captures these ligands before they can reach their natural receptors on muscle cells.
In laboratory research and animal models, ACE-031 is used to investigate:
- Muscle growth support and cellular hypertrophy
- Bone health and skeletal mineral density
- Mechanisms countering muscle wasting conditions
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