ACE-031

ACE-031
ACE-031 is a soluble form of the activin receptor type IIB (ActRIIB) linked to an IgG1-Fc fragment. It acts as a ligand trap by binding and blocking myostatin, activin, GDF-11, and other TGF-β family proteins that typically limit muscle growth. This allows researchers to study how myostatin signalling affects muscle development and hypertrophy.
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ACE-031 is a fusion protein made by combining the extracellular ligand-binding part of the ActRIIB receptor with a human IgG1 Fc region. Under normal conditions, these growth factors attach to ActRIIB and activate signals that reduce muscle growth and increase muscle breakdown. ACE-031 circulates in the bloodstream and captures these ligands before they can reach their natural receptors on muscle cells.
By blocking this interaction, ACE-031 reduces myostatin activity, allowing muscle cells to grow and increase lean body mass. The Fc portion also extends its half-life, so it stays active in the body for a longer period.
ACE-031 is studied for:
- Muscle growth support
- Bone health
- Muscle wasting conditions
- Energy and metabolism effects
- Cancer-related muscle loss
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