VIP
VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide involved in numerous physiological processes, including vasodilation, neurotransmission, and smooth muscle relaxation. Widely used to investigate signalling through the VPAC1 and VPAC2 receptors, as well as cardiovascular, gastrointestinal, neurological, and immunological pathways.
VIP
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VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide involved in numerous physiological processes, including vasodilation, neurotransmission, and smooth muscle relaxation. Widely used to investigate signalling through the VPAC1 and VPAC2 receptors, as well as cardiovascular, gastrointestinal, neurological, and immunological pathways.
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VIP mediates many of its biological effects through VPAC1 and VPAC2 receptors, both of which are G protein-coupled receptors. Activation of these receptors stimulates adenylyl cyclase, leading to increased intracellular cyclic adenosine monophosphate (cAMP) levels and regulation of downstream signalling pathways. Additional signalling mechanisms, including calcium-associated pathways, may also be involved depending on the experimental system.
Research Applications
- Neuropeptide signaling
- VPAC1 and VPAC2 receptor biology
- cAMP-mediated intracellular signalling
- Gastrointestinal physiology and secretion
- Vascular regulation and vasodilation
- Respiratory physiology and bronchodilation
- Immune system modulation
- Circadian rhythm and neuroendocrine research
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